Does Disseminated Nontuberculous Mycobacterial Disease cause False-positive Determine TB-LAM Lateral Flow Assay Results?

Does Disseminated Nontuberculous Mycobacterial Disease cause False-positive Determine TB-LAM Lateral Flow Assay Results?

Nontuberculous Mycobacterial Pulmonary Disease

Tuberculosis (TB) is an infectious and transmissible disease caused by Mycobacterium tuberculosis and closely related mycobacterial species (M. bovis, M. africanum, and M. microti). These species, obligate pathogens, compose what is known as the M. tuberculosis complex. Nontuberculous mycobacterial (NTM) species are mycobacterial species other than those belonging to the Mycobacterium tuberculo...

Investigation of false-positive results given by the QuantiFERON-TB Gold In-Tube assay.

We investigated a sudden increase in the rate of positive QuantiFERON-TB Gold In-Tube results from 10% to 31% at a U.S. academic institution. Direct comparison of the TB antigen tubes with tubes from a different lot number identified that a potential problem with the TB antigen vials in a certain tube lot was the likely cause of the elevated positive rate. The underlying defect remains unknown....

Investigation of false-positive results by the QuantiFERON-TB Gold In-Tube assay

1 Madeline Slater, Julie Parsonnet, Niaz Banaei 2 3 Division of Infectious Diseases and Geographic Medicine, Department of Medicine and 4 Pathology, Stanford University School of Medicine, Palo Alto, California; Clinical 5 Microbiology Laboratory, Stanford University Medical Center, Palo Alto, California 6 7 Running Title: False-positive QuantiFERON-TB Gold In-Tube results 8 9 Corresponding aut...

Nontuberculous ( Environmental ) Mycobacterial Disease 12

12 Nontuberculous mycobacteria (NTM) are in the same family as the organisms that cause tuberculosis and leprosy, but unlike those organisms, NTM are widely dispersed in our environment, vary greatly in their ability to cause disease, and are not spread from person to person. There are about 140 different species of mycobacteria. Mycobacteria not closely related to tuberculosis or leprosy are c...